SAM-e 400mg 30 Enteric Coated Caplets. Vegan, Kosher, Non-GMO, Soy Free, Gluten Free - Mood and Joint Support - Cold Form Blister Packed.

I've been taking these for over a month and I have to say they work phenomenally. Yah has blessed me with this product. I have had depression and anxiety for 10 years. I have tried herbal teas, sound therapy, CBD, lemon balm and other herbs and supplements. Nothing and I MEAN NOTHING works like SAM-E. I've tried the genius joy brand but it's low quality and over priced. I always like to do my own personal research before I take a substance. I found that taking 800 mg to 1600 mg for depression and anxiety is the optimal dose. I tried 800 mg the first 3 days and felt that wasn't enough. So I bumped it to 1600 mg a day and it's been working amazing ever since. That is 2 pills in the morning and 2 pills in the evening. Now I'm not going to lie to you.SAM-E is harsh on the stomach but after me and my mom prayed to Yah for a solution because O didnt want to go back to taking CBD because it's not as effective as SAM-E, we were given the solutions of taking it early in the morning (further first dose), I like to take it at 4 am and then go back to sleep b4 I have to get up for work or school. And then when I'm up and moving I will EAT ONE CHOBANI YOGURT. Theflavprs that have been effectived are BLACK CHERRY, KEY LIME, SMORES, & MIXED BERRY. I am confident that any of their flavors will work for people though, it's because of the probiotics. For the evening dose I just take it b4 dinner and I am good to go. Once I started incorporating the yogurt and taking the first dose early the loose stools and stomach cramps stopped. I was literally pooping 6 to 8 times a day. Based on my personal experience the CHOBANI YOGURT is protective for the stomach. And I'm not sure on why taking it early helps but I highly recommend taking it rhat way instead 30 minutes before you have to leave because you will have to poop on a public bathroom, I'm just being honest like how I want others to be with me. In conclusion if you don't have bipolar or are taking a current anti depressant give this a shot. But if you do HAVE BIPOLAR STAY AWAY BECAUSE THIS WILL GIVE YOU MANIA, the box states this and research online says this as well. Also if you're taking an antidepressant it could have a negative reaction with the SAM-E. be safe everyone, I want all of us that suffer from depression/ anxiety to feel better and live happy- healthy lives. I no longer have suicidal thoughts and I'm less anxious and depressed. I truly have seen a change in my life. And I want you to see a change in your life too. ❤

Seems ok

I have been stuck feeling low energy for years. Constantly burnt out only thing I want to do is scroll on the phone and I’m so snappy. I saw a Tik tok and the lady said she could laugh again with her kids after taking this. Four days in and oh my gosh I found myself saying wow I can laugh again with my kids and not only can I laugh again I can play w them! Before I would get burnt out playing one game of hide and seek now I can actually play and enjoy playing with them. I can walk my dogs and it doesn’t feel like a chore, and everything seems brighter, the sun, the colors. This stuff is life changing

🧬 Methionine + ⚡ ATP ➜ 🚀 SAM-e ➜ 🎁 Methyl Donation ➜ 🧪 SAH ➜ ⚠️ Homocysteine ➜ 🔁 (🍃 Folate/5-MTHF + 🧠 B12) ➜ Methionine OR 🔁 (🍬 Betaine/TMG) ➜ Methionine OR 🛡️ (💊 B6) ➜ Cystathionine ➜ Cysteine ➜ 🧤 Glutathione 1) 🧬 Methionine + ⚡ ATP ➜ 🚀 SAM-e Your body takes methionine (an amino acid from food) and uses ATP (cell energy) to create SAM-e. SAM-e = your main “methyl donor fuel.” 2) 🚀 SAM-e ➜ 🎁 Methyl Donation SAM-e’s job is to donate a methyl group (CH₃) to many targets, like: 🧠 neurotransmitter pathways (mood-related chemistry) 🧬 DNA / gene regulation (methylation) 🧈 cell membranes (phospholipids) 🧹 detox/liver processes Think of this step as SAM-e spending its “methyl currency.” 3) After donating ➜ 🧪 SAH Once SAM-e donates, it turns into SAH (S-adenosylhomocysteine). Important: too much SAH can slow methylation (it can block methylation enzymes). 4) 🧪 SAH ➜ ⚠️ Homocysteine SAH is broken down into homocysteine. Homocysteine is a normal intermediate, but if it builds up, it can mean the cycle isn’t recycling efficiently. What happens to homocysteine? (3 main exits) 5A) ⚠️ Homocysteine ➜ 🔁 Methionine (🍃 Folate/5-MTHF + 🧠 B12 route) This is the main recycle path. Active folate (5-MTHF) + B12 help convert homocysteine back into methionine, which can then make more SAM-e. 5B) ⚠️ Homocysteine ➜ 🔁 Methionine (🍬 Betaine/TMG route) This is a backup recycling route (mainly liver/kidney). Betaine (TMG) can donate a methyl group to recycle homocysteine back into methionine. 5C) ⚠️ Homocysteine ➜ 🛡️ (💊 B6 route) ➜ Cystathionine ➜ Cysteine ➜ 🧤 Glutathione This is the antioxidant/cleanup path (“transsulfuration”). With B6, homocysteine can be converted toward cysteine (via cystathionine), which helps make glutathione (a major antioxidant).

These worked as well as a more expensive brand. They have a smell to them, but if you just pop it in your mouth and swallow with a gulp of water, it's fine. They work the same way, and do what the more expensive brands seem to do. I will order again. The most important piece is the enteric coating, which allows them to activate in your intestines not in your stomach.