---
product_id: 16887578
title: "Jarrow Formulas SAMe Supplement 400 mg - 60 Tablets - High Concentration of Active S,S Form - Supports Joint Health, Liver Function, Brain Metabolism, Balanced Mood & Antioxidant Defense - 60 Servings"
brand: "jarrow formulas"
price: "Bs.1261"
currency: BOB
in_stock: true
reviews_count: 5
category: "Jarrow Formulas"
url: https://www.desertcart.bo/products/16887578-jarrow-formulas-same-supplement-400-mg-60-tablets-high-concentration
store_origin: BO
region: Bolivia
---

# Vegan & allergen-free formula 400 mg potent SAMe per tablet Enteric-coated for max bioavailability Jarrow Formulas SAMe Supplement 400 mg - 60 Tablets - High Concentration of Active S,S Form - Supports Joint Health, Liver Function, Brain Metabolism, Balanced Mood & Antioxidant Defense - 60 Servings

**Brand:** jarrow formulas
**Price:** Bs.1261
**Availability:** ✅ In Stock

## Summary

> 💡 Elevate your wellness game with Jarrow SAMe — because feeling good is the new success.

## Quick Answers

- **What is this?** Jarrow Formulas SAMe Supplement 400 mg - 60 Tablets - High Concentration of Active S,S Form - Supports Joint Health, Liver Function, Brain Metabolism, Balanced Mood & Antioxidant Defense - 60 Servings by jarrow formulas
- **How much does it cost?** Bs.1261 with free shipping
- **Is it available?** Yes, in stock and ready to ship
- **Where can I buy it?** [www.desertcart.bo](https://www.desertcart.bo/products/16887578-jarrow-formulas-same-supplement-400-mg-60-tablets-high-concentration)

## Best For

- jarrow formulas enthusiasts

## Why This Product

- Trusted jarrow formulas brand quality
- Free international shipping included
- Worldwide delivery with tracking
- 15-day hassle-free returns

## Key Features

- • **Joint & Liver Support:** Promotes healthy connective tissue and antioxidant defenses, helping you stay active and vibrant.
- • **Mood & Cognitive Balance:** Clinically linked to mood stabilization and enhanced brain metabolism for sharper focus and emotional resilience.
- • **Power-Packed 400 mg Dose:** Delivers a clinically effective amount of SAMe to support mood, joints, and liver health.
- • **Vegan & Allergy-Friendly:** Free from gluten, soy, dairy, nuts, and more—perfect for clean, conscious lifestyles.
- • **Enteric-Coated for Superior Absorption:** Ensures SAMe bypasses stomach acid, maximizing active delivery where your body needs it most.

## Overview

Jarrow Formulas SAMe Supplement delivers a potent 400 mg dose of naturally derived S-Adenosyl Methionine in an enteric-coated, vegan-friendly tablet. Designed to support joint health, liver function, balanced mood, and brain metabolism, this 60-day supply is free from common allergens and optimized for maximum absorption. Trusted by thousands seeking natural mood and cognitive support, it’s a premium choice for proactive health management.

## Description

Jarrow Formulas SAMe provides SAM-e (S-Adenosyl Methionine), a naturally derived compound that plays a role in supporting various biochemical systems in the body.* Each tablet of Jarrow Formulas SAM-e provides 400 mg of SAM-e to provide benefits. Jarrow Formulas SAM-e offers a wide array of benefits that can support various aspects of your health and well-being.* SAM-e supports joint health, and liver function.* Jarrow Formulas SAM-e is non-GMO, vegan-friendly, and gluten free, making it an ideal choice for those with dietary restrictions.* These tablets are also wheat free, soy free, dairy free, egg free, fish/shellfish free, peanut/nut free, and sesame free.* Taking Jarrow Formulas SAM-e is simple and convenient. Adults should take 1 tablet per day on an empty stomach or as directed by your qualified healthcare professional.* At Jarrow Formulas, we aren't your typical vitamin company. We believe everyone has the right to feel good in their own body. Jarrow Formulas original goal has always remained the same: To design superior dietary supplements that help empower individuals to take charge of their own health.*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Review: I am so amazed with this product - I have used desertcart for almost 10 years and I've never written a review because I'm just not the type to do so, nor do I have the time or energy to put in the effort. However, I am so amazed with this product, I have a burning desire to share my positive experience. First of all, I have tried EVERYTHING to help depression. Seriously. I've always experienced prescription drugs to be too much for my system no matter the dosing and the time I waiting the side effect out. With Sam-e, I started out taking 400s right as I woke up. (30 min before breakfast.) The first 5-6 days, I experienced heightened anxiety and insomnia. I remember one night just wide eyed thinking that it was ridiculous that I couldn't sleep. After about 5-6 days, I started to sleep normal again and the anxiety tapered off. Before I even realized it, I was just level. It's hard to explain. The edge was taken off. I've been really stressed out and depressed, and I'm in my second year of nursing school. Now, 2 months on Sam-e, the stress is minimal because I am able to control my perception on situations and life so much better. Control is something I've never had with my emotions or mental being. I've struggled with a little OCD, depression to where I wouldn't leave the house, sometimes not get out of bed and I would sit in my car for hours because I just felt like I couldn't move. I wouldn't even go into a grocery store because I didn't feel confident to deal with people or strangers. Sam-e has saved my life! That sounds so cliché but I am being as authentic as I can here. I don't feel like I'm on anything and I have zero side effects. I've not felt like I needed to adjust my dosing, as some people feel they need to bump up to higher doses to feel more of an affect. I did do a lot of research before taking Sam-e and I do take folic acid and a B complex. Apparently, those two supplements prevent a certain chemical from building up in your body from taking Sam-e. All in all, I am just so grateful to be one of the 5 star reviewers. I remember reading these same reviews praying that Sam-e would be a miracle for me and it is! My best advice is it doesn't hurt to try. Give it time.. If you feel the anxiety and insomnia, just hang in there. And take the folic acid and b complex with it; maybe that makes a difference. Wish you the best!
Review: Better than an anti-depressant. - For years, I was placed on chemical anti-depressants that masked my symptoms, but gave me horrid side effects and no other benefits besides lifting my mood a bit. SAM-e is a naturally occurring compound. Many people that are diagnosed with depression simply do not produce enough SAM-e naturally (whether due to genetics, poor diet, etc...) and SAM-e is all they need to see relief. I threw my anti-depressants in the garbage one day and went through horrible withdrawals. I was having a lot of difficulty and needed something that could help. I scoured the internet for natural solutions and came upon this. Everywhere I looked, they said that Jarrow Formulas was the best quality available. Within a week of taking SAM-e, I could function. Things were looking up. I was me again. That was two summers ago and would not be without it since. Here's the kicker: I recently found out I have MTHFR which is (quoting from a site so that I can explain it properly) "a genetic mutation where homocysteine levels are too high in the brain due to the fact that not enough Methylfolate is available to convert the homocysteine into Methionine, SAMe and Glutathione. Methylfolate (L-MTHF or 5-MTHF) is like a wizard changing the bad guy (Homocysteine) into good guys (SAMe and Glutathione)." So it turns out I have a medical lack of SAM-e. Also, those with MTHFR can find themselves with high folate or high B12. i.e. the body will have problems converting inactive forms of folate and B12 (like those in normal multivitamins/enriched foods) to the active forms. So the inactive folate or B12 will simply build up in your serum, also inhibiting the active forms. Ultimately, this = vitamin b12 deficiency, because everything is inhibited. MTHFR is linked to Fibromyalgia, Chronic Fatigue Syndrome, Migraines, IBS, Depression, and Alzheimer's. Alzheimer's runs in my family. Recent studies have shown that "a line of evidence suggested abnormally low levels of endogenous SAM (S-Adenosyl methionine) may play an important role in the development of Alzheimer's disease, and that SAM may therefore have therapeutic potential in the treatment of Alzheimer's disease." Other research has said "this effect is likely due to vitamin B12 deficiencies, which result in neurologic defects due to the inability to conduct one carbon transfers (with folate) in the absence of B12." I also have IBS, and SAM-e seems to help incredibly. I notice if I forget a dose. I take for my mind, my mood, my brain, and hopefully protect myself from Alzheimer's if the studies I have quoted and researched for so long are true! I love Jarrow Formulas because this SAM-e is great quality and at a reasonable price. --Anyone that is sick often or has the symptoms of MTHFR, please look into it! A simple blood test shows it.

## Features

- One (1) bottle of Jarrow Formulas SAMe 400 mg Extra Strength Vegan Naturally Derived SAMe Dietary Supplement, SAMe Supplement Supports Joint Health, Liver Health and Brain Health, for a 60-day supply*
- SAMe balanced mood support supplement formula provides 400 mg SAMe from 800 mg of SAMe tosylate disulfate and is enteric-coated to ensure a biologically active product
- SAMe supports brain metabolism and the production of healthy connective tissue for joint support; SAMe metabolism supports glutathione synthesis for antioxidant and liver support*
- These brain supplements for memory are vegan, wheat free, gluten free, soy free, dairy free, egg free, fish free, shellfish free, peanut free, tree nut free and sesame free for an allergy friendly supplement
- Suggested Use: Adults take one joint health and mood support supplement a day on an empty stomach or as directed by your qualified healthcare professional; *These statements have not been evaluated by the Food and Drug Administration; this product is not intended to diagnose, treat, cure, or prevent any disease

## Technical Specifications

| Specification | Value |
|---------------|-------|
| ASIN  | B00V3M9CYY |
| Best Sellers Rank | #26,566 in Health & Household ( See Top 100 in Health & Household ) #1,030 in Blended Vitamin & Mineral Supplements #2,017 in Sales & Deals |
| Customer Reviews | 4.2 4.2 out of 5 stars (1,322) |
| Date First Available  | March 26, 2015 |
| Is Discontinued By Manufacturer  | No |
| Item model number  | SAM460 |
| Manufacturer  | Jarrow Formulas |
| Product Dimensions  | 1.75 x 3.25 x 6 inches; 3.36 ounces |

## Product Details

- **Brand:** Jarrow Formulas
- **Diet Type:** Vegan, Vegetarian
- **Flavor:** Unflavored
- **Item Form:** Tablet
- **Item Weight:** 3.36 ounces
- **Item dimensions L x W x H:** 1.75 x 3.25 x 6 inches
- **Primary Supplement Type:** Vitamin
- **Product Benefits:** Bone & Joint Support, Stress Relief
- **Special Ingredients:** Amino Acid
- **Unit Count:** 60 Count

## Images

![Jarrow Formulas SAMe Supplement 400 mg - 60 Tablets - High Concentration of Active S,S Form - Supports Joint Health, Liver Function, Brain Metabolism, Balanced Mood & Antioxidant Defense - 60 Servings - Image 1](https://m.media-amazon.com/images/I/71LmfirQxxL.jpg)

## Available Options

This product comes in different **Size** options.

## Customer Reviews

### ⭐⭐⭐⭐⭐ I am so amazed with this product
*by W***0 on October 23, 2015*

I have used Amazon for almost 10 years and I've never written a review because I'm just not the type to do so, nor do I have the time or energy to put in the effort. However, I am so amazed with this product, I have a burning desire to share my positive experience. First of all, I have tried EVERYTHING to help depression. Seriously. I've always experienced prescription drugs to be too much for my system no matter the dosing and the time I waiting the side effect out. With Sam-e, I started out taking 400s right as I woke up. (30 min before breakfast.) The first 5-6 days, I experienced heightened anxiety and insomnia. I remember one night just wide eyed thinking that it was ridiculous that I couldn't sleep. After about 5-6 days, I started to sleep normal again and the anxiety tapered off. Before I even realized it, I was just level. It's hard to explain. The edge was taken off. I've been really stressed out and depressed, and I'm in my second year of nursing school. Now, 2 months on Sam-e, the stress is minimal because I am able to control my perception on situations and life so much better. Control is something I've never had with my emotions or mental being. I've struggled with a little OCD, depression to where I wouldn't leave the house, sometimes not get out of bed and I would sit in my car for hours because I just felt like I couldn't move. I wouldn't even go into a grocery store because I didn't feel confident to deal with people or strangers. Sam-e has saved my life! That sounds so cliché but I am being as authentic as I can here. I don't feel like I'm on anything and I have zero side effects. I've not felt like I needed to adjust my dosing, as some people feel they need to bump up to higher doses to feel more of an affect. I did do a lot of research before taking Sam-e and I do take folic acid and a B complex. Apparently, those two supplements prevent a certain chemical from building up in your body from taking Sam-e. All in all, I am just so grateful to be one of the 5 star reviewers. I remember reading these same reviews praying that Sam-e would be a miracle for me and it is! My best advice is it doesn't hurt to try. Give it time.. If you feel the anxiety and insomnia, just hang in there. And take the folic acid and b complex with it; maybe that makes a difference. Wish you the best!

### ⭐⭐⭐⭐⭐ Better than an anti-depressant.
*by O***A on September 23, 2013*

For years, I was placed on chemical anti-depressants that masked my symptoms, but gave me horrid side effects and no other benefits besides lifting my mood a bit. SAM-e is a naturally occurring compound. Many people that are diagnosed with depression simply do not produce enough SAM-e naturally (whether due to genetics, poor diet, etc...) and SAM-e is all they need to see relief. I threw my anti-depressants in the garbage one day and went through horrible withdrawals. I was having a lot of difficulty and needed something that could help. I scoured the internet for natural solutions and came upon this. Everywhere I looked, they said that Jarrow Formulas was the best quality available. Within a week of taking SAM-e, I could function. Things were looking up. I was me again. That was two summers ago and would not be without it since. Here's the kicker: I recently found out I have MTHFR which is (quoting from a site so that I can explain it properly) "a genetic mutation where homocysteine levels are too high in the brain due to the fact that not enough Methylfolate is available to convert the homocysteine into Methionine, SAMe and Glutathione. Methylfolate (L-MTHF or 5-MTHF) is like a wizard changing the bad guy (Homocysteine) into good guys (SAMe and Glutathione)." So it turns out I have a medical lack of SAM-e. Also, those with MTHFR can find themselves with high folate or high B12. i.e. the body will have problems converting inactive forms of folate and B12 (like those in normal multivitamins/enriched foods) to the active forms. So the inactive folate or B12 will simply build up in your serum, also inhibiting the active forms. Ultimately, this = vitamin b12 deficiency, because everything is inhibited. MTHFR is linked to Fibromyalgia, Chronic Fatigue Syndrome, Migraines, IBS, Depression, and Alzheimer's. Alzheimer's runs in my family. Recent studies have shown that "a line of evidence suggested abnormally low levels of endogenous SAM (S-Adenosyl methionine) may play an important role in the development of Alzheimer's disease, and that SAM may therefore have therapeutic potential in the treatment of Alzheimer's disease." Other research has said "this effect is likely due to vitamin B12 deficiencies, which result in neurologic defects due to the inability to conduct one carbon transfers (with folate) in the absence of B12." I also have IBS, and SAM-e seems to help incredibly. I notice if I forget a dose. I take for my mind, my mood, my brain, and hopefully protect myself from Alzheimer's if the studies I have quoted and researched for so long are true! I love Jarrow Formulas because this SAM-e is great quality and at a reasonable price. --Anyone that is sick often or has the symptoms of MTHFR, please look into it! A simple blood test shows it.

### ⭐⭐⭐⭐⭐ Review
*by M***. on May 10, 2025*

Súper buenas, he notado el cambio que he tenido en el estado de ánimo y tengo mucho más energía, me hacen sentir muy bien

## Frequently Bought Together

- Jarrow Formulas SAMe 400 mg, Supports Joint Health, Liver Function, Brain Metabolism, 60 Tablets, Up To a 60 Day Supply
- Jarrow Formulas® SAMe 200 mg, Supports Joint Health, Liver Function, Brain Metabolism, 60 Tablets, Up To A 60 Day Supply
- Jarrow Formulas Magnesium L-Threonate, MagMind Magtein Brain Supplements for Memory Support, 90 Veggie Capsules, Up to a 30 Day Supply

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*Product available on Desertcart Bolivia*
*Store origin: BO*
*Last updated: 2026-02-23*