--- product_id: 255644787 title: "Doctor's Best, SAM-e, 400 mg, 60 Enteric Coated Tablets" brand: "doctor's best" price: "FREE" currency: BOB in_stock: false category: "Doctor's Best" url: https://www.desertcart.bo/products/255644787-doctors-best-sam-e-400-mg-60-enteric-coated-tablets store_origin: BO region: Bolivia --- # 100% vegan & allergen-free 400 mg potent dose 18 clinical trials proven Doctor's Best, SAM-e, 400 mg, 60 Enteric Coated Tablets **Brand:** doctor's best **Price:** FREE **Availability:** ❌ Out of Stock ## Summary > 💼 Elevate your mood and mobility with science-backed SAMe power! ## Quick Answers - **What is this?** Doctor's Best, SAM-e, 400 mg, 60 Enteric Coated Tablets by doctor's best - **How much does it cost?** FREE with free shipping - **Is it available?** Currently out of stock - **Where can I buy it?** [www.desertcart.bo](https://www.desertcart.bo/products/255644787-doctors-best-sam-e-400-mg-60-enteric-coated-tablets) ## Best For - doctor's best enthusiasts ## Why This Product - Trusted doctor's best brand quality - Free international shipping included - Worldwide delivery with tracking - 15-day hassle-free returns ## Key Features - • **Double Strength Dose:** 400 mg of pure, active S,S-SAMe per tablet for maximum efficacy. - • **Premium Italian Quality:** Pharmaceutical-grade SAMe with highest active isomer concentration on the market. - • **Clean & Conscious Formula:** Vegan, gluten-free, soy-free—crafted for the mindful professional. - • **Clinically Proven Support:** Backed by 18 controlled human trials over 40 years for mood, joint, and liver health. - • **Advanced Joint & Mood Boost:** Promotes joint comfort, mobility, and neurotransmitter synthesis for balanced wellbeing. ## Overview Doctor's Best SAM-e 400 mg delivers a potent, pharmaceutical-grade dose of the active S,S isomer of SAMe, clinically proven to support mood enhancement, joint comfort, and liver detoxification. This vegan, gluten-free, and soy-free formula is crafted with premium Italian SAMe, ensuring maximum bioavailability and efficacy for professionals seeking holistic cognitive and physical wellness. ## Description SAMe 400 contains 400 mg of active SAMe in each tablet. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none. S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissue including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones. The manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in Double-Strength SAMe 400 is processed to yield the highest available percentage of the active pure S,S form on the market. SAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement, and promote joint comfort.* SAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.* SAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes detoxification and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.* ## Features - Double Strength Science - Based Nutrition Supports Mood, Liver, Joint, & Cognition Dietary Supplement Non - GMO Gluten Free Soy Free Vegetarian At Doctor's Best, SAM - e is a trusted ally for mood, joint, and liver health. Our Adonat Premium SAMe formula is carefully crafted to support cellular functions, aid in cognition, and fuel crucial methylation reactions, vital for overall well - being. Helps replenish SAM ## Technical Specifications | Specification | Value | |---------------|-------| | ASIN | B004YLAXOE | | ASIN | B004YLAXOE | | Age Range Description | Adult | | Allergen Information | Allergen-Free | | Best Sellers Rank | #66,741 in Health ( See Top 100 in Health ) #1,616 in Multiple Vitamin-Mineral Combination Supplements | | Brand Name | Doctor's Best | | Color | red | | Container Type | Bottle | | Customer Reviews | 4.5 4.5 out of 5 stars (3,336) | | Customer reviews | 4.5 4.5 out of 5 stars (3,336) | | Diet Type | Gluten Free | | Dosage Form | Tablets | | Flavor | other | | Global Trade Identification Number | 00753950002524 | | Is Discontinued By Manufacturer | No | | Item Dimensions | 8.3 x 5.1 x 15.6 centimeters | | Item Form | Capsule | | Item Highlight | for Men & Women, SAMe 400 mg for Liver, Joint Health, & Cognition Support, Gluten Free, Soy Free, Vegetarian, Non GMO | | Item Weight | 0.2 Pounds | | Item model number | DRB-00252 | | Manufacturer | Doctor's Best | | Manufacturer | Doctor's Best | | Manufacturer Part Number | DRB-00252 | | Material Features | Vegan | | Material Type Free | Gluten Free / Soy Free | | Model Name | SAM-e 400mg | | Model Number | DRB-00252 | | Number of Items | 60 | | Primary Supplement Type | Other | | Product Benefits | Detoxing | | Product Dimensions | 8.26 x 5.08 x 15.57 cm; 90.72 g | | Special Ingredients | Amino Acid | | Specific Uses For Product | Joint Relief | | Total Servings Per Container | 60 | | UPC | 753950002524 367157342781 | | Unit Count | 60.00 Count | ## Product Details - **Brand:** Doctor's Best - **Diet type:** Gluten Free - **Flavour:** other - **Item dimensions L x W x H:** 8.3 x 5.1 x 15.6 centimeters - **Item form:** Capsule - **Item weight:** 0.2 Pounds - **Primary supplement type:** Other - **Product benefits:** Detoxing - **Special ingredients:** Amino Acid - **Unit count:** 60.00 Count ## Images ![Doctor's Best, SAM-e, 400 mg, 60 Enteric Coated Tablets - Image 1](https://m.media-amazon.com/images/I/61qTxsnqhPL.jpg) ## Available Options This product comes in different **Size** options. ## Questions & Answers **Q: What are the benefits of Doctor’s Best SAM-e Double Strength?** A: This formula helps support emotional well-being, cognitive function, joint comfort, mobility, and liver health as part of overall wellness support.* **Q: Why are the tablets enteric coated?** A: The enteric coating is designed to help protect SAM-e through the stomach and support targeted release for improved absorption and gastrointestinal tolerance.* **Q: Should I take with food or on an empty stomach?** A: Doctor’s Best recommends taking ONE enteric coated tablet daily between meals on an empty stomach for optimal absorption. Do not chew or crush the tablet. **Q: What's the daily dosage?** A: Adults should take ONE 400 mg enteric coated tablet daily, or as recommended by a nutritionally informed physician. **Q: Is Doctor’s Best SAM-e Double Strength vegetarian?** A: Yes. Doctor’s Best SAM-e Double Strength is Non-GMO, Gluten Free, Soy Free, and Vegetarian. ## Frequently Bought Together - Doctor's Best SAM-e 400 mg, Vegan, Gluten Free, Soy Free, Mood and Joint Support, 60 Enteric Coated Tablets - Doctor's Best SAM-e Mood & Joint Support & Liver Health (Pharmaceutical Grade/Non-GMO/Gluten Free/Vegetarian), Tablet, 60 Count (Pack of 1) - Doctors BEST High Absorption Magnesium Lysinate Glycinate 100% Chelated, Muscle Relaxation & Sleep Support, Non-GMO, Gluten Free, Soy Free, Vegan, 100% Chelated 240 Tablets --- ## Why Shop on Desertcart? - 🛒 **Trusted by 1.3+ Million Shoppers** — Serving international shoppers since 2016 - 🌍 **Shop Globally** — Access 737+ million products across 21 categories - 💰 **No Hidden Fees** — All customs, duties, and taxes included in the price - 🔄 **15-Day Free Returns** — Hassle-free returns (30 days for PRO members) - 🔒 **Secure Payments** — Trusted payment options with buyer protection - ⭐ **TrustPilot Rated 4.5/5** — Based on 8,000+ happy customer reviews **Shop now:** [https://www.desertcart.bo/products/255644787-doctors-best-sam-e-400-mg-60-enteric-coated-tablets](https://www.desertcart.bo/products/255644787-doctors-best-sam-e-400-mg-60-enteric-coated-tablets) --- *Product available on Desertcart Bolivia* *Store origin: BO* *Last updated: 2026-10-10*